Ten lucky people have won a place at the most exclusive launch event of the century: the grand opening of the Hotel Artemis, the first hotel on the moon. It's an invitation to die for. As their transport departs for its return to Earth and the doors seal shut behind them, the guests take the next leap for mankind.

However, they soon discover that all is not as it seems. The champagne may be flowing, but there is no one to pour it. Room service is available, but there is no one to deliver it. Besides the ten of them, they are completely alone.

When one of the guests is found murdered, fear spreads through the group. But that death is only the beginning. Being three days' journey from home and with no way to contact the outside, can any of the guests survive their stay.